Common variants in the obesity-associated genes FTO and MC4R are not associated with risk of colorectal cancer

B Yang; AP Thrift; JC Figueiredo; MA Jenkins; FR Schumacher; DV Conti; Y Lin; AK Win; PJ Limburg; SI Berndt; H Brenner; AT Chan; J Chang-Claude; M Hoffmeister; TJ Hudson; LL Marchand; PA Newcomb; ML Slattery; E White; U Peters; G Casey; PT Campbell

Journal article

Common variants in the obesity-associated genes FTO and MC4R are not associated with risk of colorectal cancer

B Yang, AP Thrift, JC Figueiredo, MA Jenkins, FR Schumacher, DV Conti, Y Lin, AK Win, PJ Limburg, SI Berndt, H Brenner, AT Chan, J Chang-Claude, M Hoffmeister, TJ Hudson, LL Marchand, PA Newcomb, ML Slattery, E White, U Peters Show all

Cancer Epidemiology | ELSEVIER SCI LTD | Published : 2016

DOI: 10.1016/j.canep.2016.07.003

Abstract

Background Obesity is a convincing risk factor for colorectal cancer. Genetic variants in or near FTO and MC4R are consistently associated with body mass index and other body size measures, but whether they are also associated with colorectal cancer risk is unclear. Methods In the discovery stage, we tested associations of 677 FTO and 323 MC4R single nucleotide polymorphisms (SNPs) 100 kb upstream and 300 kb downstream from each respective locus with risk of colorectal cancer in data from the Colon Cancer Family Registry (CCFR: 1960 cases; 1777 controls). Next, all SNPs that were nominally statistically significant (p < 0.05) in the discovery stage were included in replication analyses in da..

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